Supplement Articles - Supernutrition


Trimethylglycine (TMG), also known as betaine, has garnered attention as a health supplement for its potential benefits. Derived from the amino acid glycine and found in various foods like beets, spinach, and whole grains, TMG serves as a vital compound aiding essential bodily functions.

Beetroots have many health benefits, one of is to include TMG.

Understanding TMG’s Role

TMG’s significance lies in its role as a methyl donor, providing methyl groups crucial in biochemical reactions. Methylation, the transfer of methyl groups to molecules, influences DNA regulation, neurotransmitter synthesis, and detoxification pathways in the body. Essentially, TMG acts as a multifaceted assistant within the body’s internal mechanisms.

Health Benefits of TMG

Methylation Support

TMG contributes to DNA regulation, gene expression, repair, and overall cellular function through methylation. By providing methyl groups, it aids in maintaining proper functioning within the body.

Heart Health

Studies indicate that TMG supplementation can lower homocysteine levels, thus potentially reducing the risk of heart disease associated with elevated homocysteine levels.

Exercise Performance

Evidence suggests that TMG supplementation may enhance exercise performance, impacting muscle strength, power output, and endurance, benefiting athletes and fitness enthusiasts.

Liver Health

TMG exhibits promise in supporting liver function, potentially protecting against damage caused by various factors, including conditions like fatty liver disease.

Diverse Health Applications

TMG’s role as a methyl donor influences multiple biological processes, aiding in mitigating oxidative stress, reducing inflammation, and potentially impacting cancer prevention, depression alleviation, autism symptom management, and cognitive enhancement.

Considerations and Side Effects

While TMG shows promise, it’s crucial to consider potential side effects. Higher doses may lead to gastrointestinal discomfort such as nausea or diarrhea. Additionally, TMG might interact with certain medications, necessitating consultation with healthcare professionals, especially for individuals on medication.

Dosage and Safety

TMG supplment is available from high quality producer Life Extension.

Studies suggest a daily TMG dosage ranging from 1.5–6 grams for homocysteine management and performance enhancement. However, caution is advised for individuals with high cholesterol levels. TMG supplementation should be approached cautiously, particularly for children, pregnant or nursing mothers, or those with severe liver or kidney disease, as maximum safe dosages are not established.

Incorporating TMG Naturally

Apart from supplements, TMG is naturally found in various foods like wheat, beets, quinoa, spinach, and seafood, offering alternative sources for increasing intake.


TMG, with its diverse potential health benefits, serves as a promising compound worth exploring further in the realm of health and wellness. Responsible consumption, understanding potential side effects and interactions, and seeking professional guidance are essential before integrating TMG into a health regimen. Always prioritize informed decisions and consult healthcare experts for personalized advice when considering TMG supplementation.